Circular Dichroism reveals evidence of coupling between immunoglobulin constant and variable region secondary structure☆
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چکیده
منابع مشابه
Circular Dichroism reveals evidence of coupling between immunoglobulin constant and variable region secondary structure.
Antibodies (Ab) are bifunctional molecules with two domains, a constant region (C) that confers effector properties and a variable (V) region responsible of antigen (Ag) binding. Historically the C and V regions were considered to be functionally independent, with Ag specificity being solely determined by the V region. However, recent studies suggest that the C region can affect Ab fine specifi...
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The adaptive humoral immune response is responsible for the generation of antimicrobial proteins known as immunoglobulin molecules or antibodies. Immunoglobulins provide a defense system against pathogenic microbes and toxins by targeting them for removal and/or destruction. Historically, antibodies have been thought to be composed of distinct structural domains known as the variable and consta...
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ژورنال
عنوان ژورنال: Molecular Immunology
سال: 2010
ISSN: 0161-5890
DOI: 10.1016/j.molimm.2010.02.018